Booking.com is laying off a quarter of its workforce - more than 4,000 people - with the pandemic snuffing out travel.
Layoffs will begin next month and run through the end of the year, according to parent company Booking Holdings Inc.
Booking Holdings, based in Norwalk, Connecticut, also owns the restaurant reservation company OpenTable and Priceline.com.
The number of room reserved at Booking.com during the first quarter of this year tumbled 43 percent, to 124 million.
The company warned investors in May to brace for worse in the second financial quarter, the results of which are due Thursday.
Booking.com, based in Amsterdam, is a dominant player in Europe, where it controls more than 60 percent of online travel bookings, according to a 2018 report from Hospitality Europe. But bookings have plummeted as travel from major markets like the U.S. and China has slowed significantly.