Night-time drivers looking to get on the westbound Highway 54 ramp to Business Route 50 (Missouri Boulevard) will need to find another route Wednesday and Thursday.
A Missouri Department of Transportation news release announced the ramp will be closed overnight on April 26 and 27 for guardrail work.
The closure will start at 9 p.m. and last until 6 a.m. the next morning on both dates.
The work is subject to change if the weather were to interfere.
MoDOT also urges motorists to buckle up, put their phones down, obey traffic signs, slow down and move over when traveling through work zones.