MINNEAPOLIS (AP) - Tarvaris Jackson came off the bench for an injured Brett Favre and threw for 187 yards and two touchdowns, and the Minnesota Vikings defense dominated Buffalo in a 38-14 victory on Sunday.
Adrian Peterson rushed for 107 yards and three touchdowns on a gimpy right ankle for the Vikings (5-7), who are 2-0 under interim head coach Leslie Frazier.
Favre said he sprained his throwing shoulder, which occurred on the first series of the game after a big hit by Bills linebacker Arthur Moats. Jackson came in and led the Vikings to 31 first-half points. But he also threw three interceptions, including one that Drayton Florence returned 40 yards for a touchdown.
Florence had two interceptions for the Bills (2-10). Buffalo committed five turnovers and had just 9 yards passing in the first half to lose its second in a row following two straight wins.
The Vikings are 2-0 under interim coach Leslie Frazier, who replaced the fired Brad Childress.
Steelers 13, Ravens 10
BALTIMORE (AP) - Ben Roethlisberger threw a 9-yard touchdown pass to Isaac Redman with 2:51 left after Troy Polamalu forced a fumble with a sack of Joe Flacco, and Pittsburgh beat Baltimore to gain sole possession of first place in the AFC North.
A fierce defensive battle turned when Polamalu hit Flacco's arm on a safety blitz. The loose ball was taken 19 yards by Lamarr Woodley to the Baltimore 9, setting up Pittsburgh's lone touchdown.
After throwing two incomplete passes, Roethlisberger dumped a short toss over the middle to Redman, who broke two tackles on his way to the end zone.
Baltimore's ensuing drive ended when Flacco bounced a fourth-down pass to Ed Dickson with 33 seconds remaining.
The victory left Pittsburgh (9-3) a game ahead of the Ravens (8-4) in the division.
Cowboys 38, Colts 35 OT
INDIANAPOLIS (AP) - Peyton Manning had two interceptions returned for touchdowns and fourth of the day set up David Buehler for a 38-yard field goal that gave Dallas the win in overtime.
Manning finished 36 of 48 for 365 yards with two touchdowns and his second straight four-interception game. He's thrown a career-high 11 picks in the past three weeks with four of those going back for TDs.
Dallas (4-8) rushed for a season-high 217 yards and led most of the way thanks to Manning's miscues. The Colts (6-6) fell one game behind first-place Jacksonville in the AFC South.
When Manning's third-down pass to Jacob Tamme was deflected by Mike Jenkins, linebacker Sean Lee picked off his second pass of the day and ran it back 13 yards to the Colts 36. Six plays later, Buehler won it.
Jaguars 17, Titans 6
NASHVILLE, Tenn. (AP) - Maurice Jones-Drew ran for a career-best 186 yards and Rashad Jennings and David Garrard each ran for a touchdown for Jacksonville.
The win allowed the Jaguars (7-5) to take a one-game lead over Indianapolis for first place in the AFC South. The Colts lost to Dallas in overtime.
The Jaguars took control on the ground from the start on a windy, cold day. They scored on their opening drive by running through and over the Titans to split the season series.
Tennessee (5-7) started veteran Kerry Collins at quarterback, but the Titans were unable to avoid their fifth straight loss. The Titans have now gone 13 quarters without scoring a touchdown.
Falcons 28, Bucs 24
TAMPA, Fla. (AP) - Eric Weems scored on a 102-yard kickoff return and Matt Ryan threw a 9-yard touchdown pass to Michael Jenkins as Atlanta rallied from a 10-point deficit for its sixth straight victory.
Ryan led his sixth fourth-quarter comeback of the season for the NFC South leaders, keeping a 10-play, 67-yard march alive with a 25-yard completion to Roddy White on third-and-20. The Falcons (10-2) also benefited from a couple of costly penalties on the Bucs.
Rookie LeGarrette Blount rushed for 103 yards and fullback Earnest Graham threw a 2-yard touchdown pass to John Gilmore for Tampa Bay (7-5), which fell to 0-5 against teams with winning records.
Josh Freeman drove the Bucs into Falcons territory on the team's final possession. Brent Grimes' interception ended the threat.
Chiefs 10, Broncos 6
KANSAS CITY, Mo. (AP) - Jamaal Charles rushed for 116 yards and Matt Cassel threw a 3-yard pass to Leonard Pope for the only touchdown as Kansas City avenged a 20-point loss to Denver three weeks ago.
Knowshon Moreno rushed for 161 yards for the Broncos (3-9), who are enduring one of their worst stretches in decades, losing 17 of their past 22 games under coach Josh McDaniels.
In spite of all their blunders, the Chiefs (8-4) stayed unbeaten in six home games and remained on top of the AFC West.
Chiefs coach Todd Haley, who refused to shake hands with McDaniels after losing in Denver three weeks ago, embraced his counterpart this time and even gave him a pat on the head.
Seahawks 31, Panthers 14
SEATTLE (AP) - Marshawn Lynch rushed for a career-high three touchdowns, Lofa Tatupu returned an interception 26 yards and Seattle used a 21-point third quarter to rally past Carolina.
Lynch scored on a pair of 1-yard runs in the third quarter, sandwiched around Tatupu's interception of Carolina rookie Jimmy Clausen. Lynch added a 22-yard touchdown run in the fourth quarter as Seattle (6-6) avoided an embarrassing loss and stayed even with St. Louis in the NFC West race.
Carolina (1-11) dominated the first half but couldn't hold off the Seahawks.
Rams 19, Cardinals 6
GLENDALE, Ariz. (AP) - Steven Jackson ran for 102 yards, including 27 on the game's lone touchdown, and Josh Brown kicked four field goals as St. Louis (6-6) won consecutive road games for the first time in more than three years.
The Rams (6-6) also ended an eight-game losing streak against Arizona, which dropped its seventh in a row. St. Louis remained in a first-place tie with Seattle in the weak NFC West.
Rookie quarterback John Skelton made his NFL debut for Arizona (3-9) in the fourth quarter after Derek Anderson was benched and backup Max Hall went out with a shoulder injury.
Raiders 28, Chargers 13
SAN DIEGO (AP) - Jason Campbell ran for one touchdown and threw for another, Darren McFadden ran for 97 yards and a TD for Oakland.
The loss puts a serious crimp in the playoff hopes for the four-time defending AFC West champion Chargers (6-6), who trail the Chiefs by two games with four to play. Oakland (6-6) revived a running game that had been stopped cold in two straight losses, ripping through the Chargers for 251 yards. Michael Bush ran for 95 yards.
The Raiders swept the season series for the first time since 2001.
The Chargers' streak of 18 straight December victories - which tied an NFL record for most victories in any month - came to a thudding end.
Saints 34, Bengals 30
CINCINNATI (AP) - Drew Brees threw a 3-yard touchdown pass to Marques Colston with 31 seconds left, rallying New Orleans to its fifth straight victory.
The Saints (9-3) trailed for the first time after newcomer Clint Stitser made a 47-yard field goal with 4:25 to go, putting the Bengals (2-10) up 30-27.
Plenty of time for Brees to pull it out, with the help of yet another Bengals blunder.
Brees passed Archie Manning as the Saints' career passing leader earlier in the game. His 42-yarder to Robert Meacham got New Orleans into field-goal range. On fourth-and-2 from the Cincinnati 7, the Saints lined up and tried to draw the Bengals offsides.
It worked. Lineman Pat Sims jumped, giving the Saints a first down. Brees threw his second touchdown pass on the next play, sending the Bengals to their ninth straight loss.
Packers 34, 49ers 16
GREEN BAY, Wis. (AP) - Donald Driver's catch-and-run for a 61-yard touchdown broke open a tight game in the third quarter.
Greg Jennings caught six passes from Aaron Rodgers for 122 yards and a pair of touchdowns for the Packers (8-4), who picked up a critical win as they try to make a push for the playoffs in the final month of the season.
Vernon Davis had 126 yards receiving and a touchdown for the 49ers (4-8).
It was a wintry day at Lambeau Field, with temperatures in the 20s and a stiff, steady 16-mph wind that seemed to throw off the Packers' passing game early on.
Giants 31, Redskins 7
EAST RUTHERFORD, N.J. (AP) - Brandon Jacobs and Ahmad Bradshaw ran for two touchdowns apiece and New York won easily.
Jacobs ran eight times for 103 yards and scored on jaunts of 8 and 28 yards, while Bradshaw had 97 yards and TD runs of 4 and 10 yards as the Giants (8-4) moved back into first-place tie with Philadelphia in the NFC East.
A harried Donovan McNabb threw a 33-yard touchdown pass to Anthony Armstrong for Washington (5-7), which saw its playoff hopes further dimmed with its fifth loss in seven games. The Redskins had six turnovers.
Bears 24, Lions 20
DETROIT (AP) - Jay Cutler threw a go-ahead touchdown pass to Brandon Manumaleuna one play after a questionable call midway through the fourth quarter to lift Chicago.
The NFC North-leading Bears (9-3) took advantage of referee Ed Hochuli flagging Ndamukong Suh for unnecessary roughness. Suh hit Cutler's shoulder pads hard from behind when the quarterback was running downfield. Cutler then connected with Manumaleuna on a 7-yard pass with 8:39 left.
Detroit drove to the Chicago 34 before a sack led to a punt.
The Lions (2-10) have lost five straight this season and an NFL-record 19 within the division for the longest skid since the 1970 merger.
Browns 13, Dolphins 10
MIAMI (AP) - Mike Adams' interception set up a short field goal on the final play, and Cleveland overcame a comedy of errors.
When Browns lineman David Bowens deflected Chad Henne's third-down pass, Adams snatched the ball and ran 25 yards to the 2. On fourth down, Phil Dawson kicked a 23-yard field goal for the win.
Cleveland (5-7) won for the fourth time in six games, and for the first time in Miami since 1970. The Dolphins (6-6) lost for the seventh time in their past eight home games.
Mistakes plagued both teams, but the Browns took the lead in the third quarter with a 94-yard touchdown drive. The Dolphins' Dan Carpenter kicked a 60-yard field goal, which tied for the fifth-longest in NFL history.