Braxton Miller helped make Urban Meyer's first game as Ohio State coach a record-breaking romp for the Buckeyes.
Meanwhile, the new era at Penn State got off to a disappointing start thanks to another team from the state of Ohio.
In Columbus, Miller rushed for 161 yards, a record for an Ohio State quarterback, and threw for two scores and 207 yards as the 18th-ranked Buckeyes beat Miami (Ohio) 56-10.
Meyer, who won two national titles at Florida, is unbeaten in 11 openers. He had worked as a TV analyst a year ago after stepping down from the Gators job due to health and family considerations.
He was hired last November to revive the beleaguered Buckeyes.
Bill O'Brien was hired by Penn State to lead the Nittany Lions in a new direction and replace the late Joe Paterno.
Penn State had an 11-point lead at the half, but Ohio quarterback Tyler Tettleton accounted for three second-half touchdowns to hand O'Brien a 24-14 loss at State College, Pa.
Matt McGloin threw for 260 yards and two touchdowns guiding Penn State's new-look offense.
There were some other changes, too: players' names on the backs of the uniforms, and blue ribbons on the back of the helmets to show support for victims of child sexual abuse.
No. 1 USC 39, HAWAII 10
LOS ANGELES (AP) - Marqise Lee caught a 75-yard touchdown pass on the first play from scrimmage and returned a kickoff 100 yards for a score, and No. 1 Southern California rolled.
Matt Barkley kicked off his Heisman Trophy campaign with 377 yards passing and four touchdowns, and Lee caught 10 passes for 197 yards for the Trojans (1-0), whose offensive stars were every bit as impressive as expected in their first game since their two-year NCAA bowl ban ended.
Silas Redd rushed for 57 yards and a touchdown on a team-leading nine carries in the Penn State transfer's debut at USC, which led 35-0 at halftime and coasted to its 15th consecutive season-opening victory.
Robert Woods caught six passes for 42 yards and two TDs, and tight end Xavier Grimble caught Barkley's final scoring throw in the fourth quarter.
No. 3 LSU 41, North Texas 14
BATON ROUGE, La. (AP) - Kenny Hilliard rushed for 141 yards and two touchdowns, and LSU opened its season with an easy victory.
While the heavily favored Tigers were never threatened, their performance did not always thrill a Death Valley crowd that eagerly anticipated the debut of Zach Mettenberger as starting quarterback.
Mettenberger, who was briefly sidelined by a vicious sack, was 19 of 26 for 192 yards, an interception and a touchdown. But LSU didn't really need to throw in a game decided by its overwhelming defense and a running game that accounted for 316 yards, including 123 by Alfred Blue.
Derek Thompson completed only 8 of 21 passes, but two passes were scoring strikes of 80 and 15 yards to Brelan Chancellor.
No. 6 GEORGIA 45, BUFFALO 23
ATHENS, Ga. (AP) - Freshman Todd Gurley ran for three touchdowns, Aaron Murray threw three scoring passes and Georgia overcame a sloppy first half.
Gurley didn't start but may have emerged as the Bulldogs' future at tailback with his eight carries for 100 yards, including scoring runs of 10 and 55 yards. He added a 100-yard kickoff return for a touchdown in the first quarter.
Georgia, favored by 37Â½ points, led only 24-16 at halftime before pulling away in the season opener for both teams.
Branden Oliver, coming off his school-record 1,395 yards rushing in 2011, had 30 carries for 111 yards and a 2-yard touchdown run for the Bulls.
No. 7 FLORIDA STATE 69, Murray State 3
TALLAHASSEE, Fla. (AP) - Lonnie Pryor, James Wilder Jr., and Debrale Smiley combined for seven rushing touchdowns to lead Florida State.
Pryor ran for three TDs, and Smiley and Wilder added two apiece. Wilder finished with 106 yards rushing.
Florida State scored on their first touch of the new season on Rashad Greene's 47-yard punt return just 89 seconds into the game.
EJ Manuel passed for 188 yards and a touchdown before retiring midway in the third quarter.
Murray State's Casey Brockman passed for 117 yards, but was intercepted once and sacked six times, including four by Bjoern Werner.
The Seminoles totaled 606 yards while holding Murray State, a Football Championship Subdivision school, to 156 yards
No. 10 ARKANSAS 49, JACKSONVILLE STATE 24
FAYETTEVILLE, Ark. (AP) - Tyler Wilson set the school record for yards passing in a season opener, finishing 19 of 27 passing for 367 yards and three touchdowns for Arkansas.
Two of Wilson's touchdowns went to tight end Chris Gragg, who finished with seven catches for 110 yards as the No. 10 Razorbacks (1-0) won their first game under coach John L. Smith.
Brandon Mitchell, the former backup quarterback turned starting receiver, joined in the fun with four catches for 122 yards and Javontee Herndon caught four passes for 96 yards.
The Gamecocks (0-1), coached by former Razorbacks coach Jack Crowe, led 14-7 in the first half. Marques Ivory had a pair of touchdown passes, while Alan Bonner had eight catches for 107 yards.
No. 11 WEST VIRGINIA 69, MARSHALL 34
MORGANTOWN, W.Va. (AP) - Geno Smith threw for 323 yards and four touchdowns to lead the Mountaineers past Marshall.
In the final scheduled game between the state's only Bowl Subdivision teams, it marked West Virginia's highest-scoring season opener in school history.
Smith kept the momentum going from his six-TD performance from the Orange Bowl.
The senior completed 32 of 36 passes and set a school record for career completions before sitting out most of the fourth quarter
The Mountaineers compiled 655 total yards, more than any game last year, and got the balance they've sought from their running game. Shawne Alston ran for 123 yards and two scores.
No. 12 WISCONSIN 26, NORTHERN ILLINOIS 21
MADISON, Wis. (AP) - Montee Ball rushed for 120 yards and a touchdown, and Wisconsin needed a big defensive play to survive a fourth-quarter scare.
Wisconsin's defense didn't allow Northern Iowa past the 50-yard line until the 4:27 mark in the third quarter - but then the Badgers nearly melted down.
Leading 26-7 in the fourth quarter, Wisconsin allowed Northern Iowa quarterback Sawyer Kollmorgen to throw a pair of long touchdowns to David Johnson, cutting the lead to five. With the Panthers facing fourth-and-1 at the Wisconsin 41-yard line, defensive lineman Ethan Hemer tipped the ball at the line of scrimmage to stop the drive.
No. 14 CLEMSON 26, AUBURN 19
ATLANTA (AP) - Andre Ellington rushed for 231 yards, DeAndre Hopkins set a school record with 13 receptions and Clemson opened the season with a victory.
Playing before a 50-50 crowd at the Georgia Dome - basically halfway between the two campuses - Clemson shook off any hangover from last season's embarrassing 70-33 loss to West Virginia in the Orange Bowl and showed plenty of offense against Auburn even without star receiver Sammy Watkins, who was suspended for the first two games after an offseason drug arrest.
The second half was a battle of field goals before Tajh Boyd lofted a 4-yard touchdown pass to Hopkins, who made a brilliant, twisting catch in the corner of the end zone with 9:17 remaining.
Both teams kicked four field goals. Cody Parkey connected from 37, 46, 27 and 36 yards for Auburn, the last of them putting his team ahead with 12;50 remaining. Chandler Catanzaro was just as accurate for Clemson, booting it through from 24, 40, 37 and 18 yards.
Tre Mason led Auburn in rushing with 107 yards.
No. 15 TEXAS 37, WYOMING 17
AUSTIN, Texas (AP) - Joe Bergeron and Malcolm Brown both rushed for more than 100 yards and combined for three touchdowns to lead Texas.
Texas quarterback David Ash, who won the starting job over Case McCoy in training camp, was an efficient 20-of-27 passing for 156 yards and a touchdown to Jaxon Shipley.
Bergeron had 110 yards and scored Texas' first touchdown on a 1-yard run in first quarter. He put the game away with a 17-yard TD in the fourth. Brown ran for 105 yards for Texas (1-0).
Robert Herron had touchdown catches of 82 and 22 yards for Wyoming (0-1). Cowboys quarterback Brett Smith passed for 276 yards but threw two interceptions in the second quarter that set up Texas touchdowns.
No. 17 NEBRASKA 49, SOUTHERN MISS 20
LINCOLN, Neb. (AP) - Taylor Martinez threw for a career-high 354 yards and matched his best with five touchdown passes to lead Nebraska.
The Huskers won their nation-leading 27th straight opener.
Nebraska played the last three quarters without Rex Burkhead. The 1,300-yard rusher last season went out with a sprained ligament in his left knee after opening the scoring with a career-long 57-yard run.
Backup Ameer Abdullah ran 15 times for 81 yards and made an acrobatic catch for an 11-yard TD.
Southern Miss backup quarterback Anthony Alford carried 15 times for 84 yards in his first college game.
No. 18 OHIO STATE 56, MIAMI, OHIO, 10
COLUMBUS, Ohio (AP) - Braxton Miller threw for two scores, including Devin Smith's highlight-reel, one-handed catch, for the Buckeyes.
The slow-starting Miller, who stutter-stepped for a 65-yard score just 17 seconds into the second half, finished 14 of 24 passing for 207 yards. He also hit Corey Brown on a 5-yard TD pass.
After Miller's long run made it 28-3, Bradley Roby recovered a high Miami punt snap in the end zone and the rout was on.
Travis Howard had two interceptions and Carlos Hyde scored on 4- and 8-yard runs for Ohio State.
No. 19 OKLAHOMA STATE 84, SAVANNAH STATE 0
STILLWATER, Okla. (AP) - Freshman Wes Lunt completed all 11 of his passes in a brief first outing as the new starting quarterback for Oklahoma State.
The defending Big 12 champions drove for touchdowns on their first five possessions to take a 35-0 lead late in the first quarter, and then used the rest of the game as a scrimmage to get playing time for their reserves.
Joseph Randle ran for 107 yards and two TDs on just six carries and Desmond Roland added 104 yards rushing, and Jeremy Smith ran for three scores as the Cowboys opened with an all-too-easy victory after losing stars Justin Blackmon and Brandon Weeden in the first round of the NFL draft.
The lopsided result was hardly a surprise. Savannah State, one of the worst teams from a lower division, had won only four games in against Football Championship Subdivision competition in 10 years and was playing team from the FBS for the first time.
No. 22 KANSAS STATE 51, MISSOURI STATE 9
MANHATTAN, Kan. (AP) - Collin Klein threw for 169 yards and two touchdowns, John Hubert ran 95 yards for a fourth-quarter score and Kansas State pulled away late to beat Missouri State.
Hubert finished with 152 yards rushing, Braden Wilson and Daniel Sams added touchdown runs, and Tramaine Thompson returned a punt 89 yards for another score as the Wildcats (1-0) tuned up for next week's showdown with Miami with an impressive second-half scoring binge.
The game was tied 9-9 early in the third quarter before Kansas State piled up 42 straight points against the team picked to finish last in the Missouri Valley Conference.
No. 23 FLORIDA 27, BOWLING GREEN 14
GAINESVILLE, Fla. (AP) - Mike Gillislee had a career-high 148 yards rushing and two touchdowns, helping Florida beat Bowling Green.
The performance was far from perfect for the Gators, who struggled part of the game on offense and failed to generate much pressure on defense. Still, it was enough for Florida to win its 23rd consecutive opener. The streak is the second longest in the nation behind Nebraska (27).
The Gators can thank Gillislee, Frankie Hammond and two missed field goals for the latest one.
Gillislee scored on runs of 15 and 38 yards in the second quarter. Hammond turned a short pass into a 50-yard score early in the fourth. Bowling Green could have had a second-half lead, but fifth-year senior Stephen Stein missed field-goal attempts of 31 and 29 yards.