KANSAS CITY - Jeremy Guthrie's debut with the Kansas City Royals was spoiled by Ryan Doumit.
The Twins' designated hitter homered from both sides of the plate and drove in four runs to lead Minnesota to a 7-5 victory Sunday.
Guthrie (3-10), acquired Friday in a trade with Colorado for Jonathan Sanchez, yielded four runs on five hits and three walks in five innings. The right-hander, who led the National League in home runs allowed with 21, hung a breaking ball on a 1-1 count to Doumit, who hit it out to right.
"I was disappointed," Guthrie said. "I wanted to come out and help get a win."
Minnesota scored four runs with two outs in the third. Doumit had a two-run single with the bases loaded and Brian Dozier hit a two-run double off the left-field wall. Guthrie walked Ben Revere and Joe Mauer during the inning and both scored.
"The two-run hits hurt, but honestly I threw the ball the way I wanted to and the hitters hit good pitches," Guthrie said. "I think the biggest mistakes were the walks. I had Joe down 0-2 and walked him. I think I executed my pitches, but they were able to hit them. But I got myself in trouble with the walks."
Guthrie threw 30 of his 91 pitches in the third inning, when the Twins sent eight batters to the plate.
"I thought he threw the ball OK," Royals manager Ned Yost said. "He had a rough third inning, but I didn't think he made a horrible pitch. He kept the ball down in the zone and I don't think he elevated all day. He made good pitches and I thought they hit good pitches. I was impressed."
Kansas City's rotation had a 7.38 ERA during a 3-7 homestand. The Royals have lost 15-of-20 and are only a half-game in front of the Twins for last place in the AL Central.
"It's really frustrating," right fielder Jeff Francoeur said. "We just can't seem to win at home. We haven't played good baseball. We haven't pitched good and we haven't hit good. Our only saving grace I guess has been our bullpen."
Doumit became the third Twins player to go deep from both sides in a game. The others were Chili Davis (1992) and Roy Smalley (1986).
"That's great company," Doumit said.
He homered to lead off the second inning swinging left-handed, then opened the sixth with his ninth home run batting right-handed against reliever Tim Collins. It was Doumit's sixth career multihomer game, the second this season.
Hitting .354 in his past 26 games, Doumit matched his career high with four RBI.
Samuel Deduno (1-0), who made six relief appearances the past two years with San Diego and Colorado, picked up his first big-league victory. He limited the Royals to one run and six singles over 61â„3 innings.
Lorenzo Cain's sacrifice fly in the fourth scored Mike Moustakas with the only run off Deduno, who was making his third major-league start.
The Twins bunched three hits and two walks off Guthrie in a four-run third. Jamey Carroll led off the inning with a single and, with one out, Revere and Mauer walked.
It appeared Guthrie might escape unscathed after Josh Willingham's infield popup for the second out, but Doumit delivered a two-run single. Dozier doubled off the left-field wall to drive in two more runs.
Billy Butler homered, his 19th, with Moustakas aboard in the eighth against Twins reliever Anthony Swarzak. Pinch-hitter Yuniesky Betancourt also connected in the Royals' two-run ninth.
"As always with Kansas City, it comes down to one or two runs," Minnesota manager Ron Gardenhire said. "You never feel like they're out of the game. We've had so many of these games. It got close at the end."
Royals SS Alcides Escobar and Yost were ejected in the ninth inning by second base umpire D.J. Reyburn. It was Escobar's first career ejection.