Comedians mark Oprah's final show with punch lines

NEW YORK (AP) - While many reacted to the final episode of "The Oprah Winfrey Show" with tears and emotion, comedians found punch lines.

On "Jimmy Kimmel Live," Kimmel sang goodbye by performing the song "End of the Road" with R&B group Boyz II Men. The tune was renamed "It's So Hard To Say Goodbye (to Oprah Winfrey)."

David Letterman, whose up-and-down relationship with Winfrey has long been chronicled, earlier lamented not being invited to the farewell gala in Chicago.

"Honest to God," said Letterman, "Every day, I get out of bed and think: "What can I do to suck up to Oprah?"'

Many turned to social media to contemplate a post-Oprah world.

Among the notable comments made on Twitter were these:

- "Apparently Oprah is responsible for life on our planet as we know it." - Kevin Nealon.

- "I miss both Oprah and Osama. Is there a way to pair them up for something?" - Michael Ian Black.

- "Oprah Winfrey is so powerful that she had the Rapture postponed until after her final show airs." - Joan Rivers.

- "It seems so unfair! Without Oprah, how are publishers going to continue their cross-fingers/hope-to-win-the-lottery business plan?" - John Hodgman.

- "Jesus will probably be the surprise guest. She got him started." - Paula Poundstone.

- "What can I say about Oprah that she hasn't already said about herself?" - Justin Stangel, co-executive producer of CBS' "Late Show."