EUGENE, Ore. (AP) - Marcus Mariota threw for 318 yards and three touchdowns and No. 3 Oregon's blur offense overwhelmed No. 7 Michigan State's stout defense in a 46-27 victory Saturday night.
Mariota's three touchdown passes - two to speedy redshirt freshman Devon Allen - gave him 69 for his career, an Oregon record.
After falling behind 27-18 early in the third quarter, Oregon (2-0) scored four straight touchdowns, two on runs by freshman Royce Freeman. He finished with 89 yards on 13 carries.
The loss snapped an 11-game winning streak for the defending Big Ten and Rose Bowl champion Spartans, who went 13-1 last season. Connor Cook threw for 343 yards, two touchdowns and two interceptions.
The Spartans (1-1) had the second-ranked total defense in the nation last year, allowing opponents an average of just over 252 yards per game. But the high-flying Oregon offense - combined with temperatures approaching 100 degrees - appeared to wear on Michigan State as the game went on.
VIRGINIA TECH 35, NO. 8 OHIO STATE 21
COLUMBUS, Ohio (AP) - Michael Brewer threw for two touchdowns and Virginia Tech's defense stood tough at the end and the Hokies stunned Ohio State.
Keyshoen Jarrett had two interceptions and Donovan Riley returned another 63 yards for a touchdown in the final minute as a record crowd of 107,517 at enlarged Ohio Stadium watched.
Brewer led the Hokies (2-0) to a 21-7 lead at the half. After his fumble led to the Buckeyes (1-1) pulling even on Ezekiel Elliott's 15-yard run early in the fourth quarter, he led a 65-yard march capped by his 10-yard scoring pass to Bucky Hodges with 8:44 left.
The defense then stymied Ohio State quarterback J.T. Barrett, the freshman taking over for injured three-year starter Braxton Miller.
NO. 16 NOTRE DAME 31, MICHIGAN 0
SOUTH BEND, Ind. (AP) - Everett Golson threw three touchdown passes and Notre Dame said so long to Michigan with Fighting Irish's most dominant performance in the historic rivalry that will take a hiatus.
Game No. 42 between in a rivalry that has been off-and-on for more than 100 years is the last scheduled. Notre Dame broke off the series a couple years ago to make room on its schedule to accommodate its new arrangement with the Atlantic Coast Conference. Michigan didn't take it well.
But with a chance to take a parting shot at the Irish, the Wolverines got hit with a haymaker and were handed their most lopsided loss in the series. And they were shut out for the first time since 1984, snapping an NCAA record streak of 376 games.
Golson was 23 for 34 for 226 yards.
NO. 14 SOUTHERN CALIFORNIA 13, NO. 13 STANFORD 10
STANFORD, Calif. (AP) - Andre Heidari kicked a career-long 53-yard field goal for Southern California with 2:30 left, and J.R. Tavai forced a fumble to end Stanford's comeback bid.
With Stanford threatening to tie or take the lead, Tavai came from Kevin Hogan's blindside to jar the ball loose. Scott Felix recovered at the 26 with 19 seconds to play, sealing new coach Steve Sarkisian's first major victory at USC (2-0, 1-0) and upending the two-time defending Pac-12 champions.
Javorius Allen ran for a career-high 154 yards, and Nelson Agholor had a career-high nine receptions for 91 yards to help the Trojans do just enough on offense to win at Stanford Stadium for the first time since 2008.
Heidari also made a 25-yard field goal in the third quarter.
The Trojans had gained 701 yards while running a conference-record 105 plays in a 52-13 win over Fresno State last week. But Stanford slowed down Cody Kessler and USC's up-tempo offense most of the afternoon.
Stanford outgained the Trojans 413 to 291 but had too many mistakes to overcome. The Cardinal committed two turnovers, eight penalties for 68 yards and missed two fields.
Stanford's 17-game home winning streak - which was the longest in the country - also ended.
NO. 19 NEBRASKA 31, MCNEESE ST. 24
LINCOLN, Neb. (AP) - Ameer Abdullah's 58-yard touchdown dash on a pass from Tommy Armstrong Jr. broke a tie with 20 seconds left in Nebraska's victory over McNeese State.
McNeese State erased a 10-point deficit to tie it at 24 with 4:21 to play. The Huskers' winning possession started with 1:14 left, and they were facing third-and-6 when Abdullah made the play of his career.
After catching a pass short of the first-down marker, he first made McNeese State's Bo Brown miss, then rammed into a pack of three defenders, bounced off Aaron Sam and zoomed past Brent Spikes.
Nebraska (2-0) improved to 11-0 against FCS opponents.
Armstrong passed for 242 yards and two touchdowns and ran for 131 yards and a TD. Abdullah, who ran for a career-high 232 yards a week ago against Florida Atlantic, was held to 54 yards on the ground.
But the senior was at his best at the end after McNeese State freshman Alex Kjellsten's 24-yard field goal tied it at 24. Abdullah finished with three catches for 96 yards.
Sam had a 98-yard interception return for touchdown for the Cowboys (0-1).
NO. 1 FLORIDA STATE 37, CITADEL 12
TALLAHASSEE, Fla. (AP) - Jameis Winston threw for 256 yards and two touchdowns and Florida State set a school record with its 18th consecutive victory.
Winston completed 22 of 27 passes and the Seminoles (2-0) scored touchdowns on all four first-half drives and field goals on his two third-quarter drives. The Heisman winner sat down with a 34-0 lead.
Aaron Miller was 3 of 11 for 46 yards and a touchdown and ran for 61 yards for the Bulldogs (0-2).
NO. 2 ALABAMA 41, FLORIDA ATLANTIC 0
TUSCALOOSA, Ala. (AP) - Blake Sims had 214 passing yards and Jake Coker threw for 202 to lead Alabama past Florida Atlantic in a game halted by lightning.
Both quarterbacks got a chance to stake a claim to the starting job for the Crimson Tide (2-0) in the one-sided game. Both schools agreed to end the game with 7:53 left.
Sims passed for two touchdowns and ran for a third in his second straight start and didn't play in the fourth quarter. He was 11-of-13 passing.
Coker went 15 of 24 with a touchdown in his first significant action, but the Florida State transfer missed some open receivers downfield.
Amari Cooker had 189 receiving yards and tied DJ Hall's 8-year-old school record with 13 catches. The Tide outgained the Owls 620-145.
NO. 4 OKLAHOMA 52, TULSA 7
TULSA, Okla. (AP) - Sterling Shepard had a career-high 177 yards receiving to help Oklahoma rout Tulsa.
Trevor Knight passed for 299 yards and two touchdowns and ran for another score. Alex Ross ran for 90 yards and a touchdown, Keith Ford rushed for 87 yards and two scores and Blake Bell, a converted quarterback who now plays tight end, caught his first career touchdown pass for the Sooners (2-0).
It was Oklahoma's sixth straight win overall and eighth in a row in the series against Tulsa (1-1).
Tulsa's Dane Evans passed for 204 yards, and Keevan Lucas caught 10 passes for 84 yards.
NO. 5 AUBURN 59, SAN JOSE STATE 13
AUBURN, Ala. (AP) - Cameron Artis-Payne ran for three touchdowns, all in the first half, and Auburn used a dominant ground game to beat San Jose State.
Auburn (2-0) had six touchdowns and 358 yards on the ground, including 112 from Artis-Payne. Quarterback Nick Marshall, making his first start of the season, ran for 103 yards, including a 27-yard touchdown on his final drive late in the third quarter.
Blake Jurich threw a 75-yard touchdown pass to Tyler Ervin in the opening quarter but had two first-half interceptions for San Jose State (1-1).
Quan Bray scored on a 55-yard punt return for Auburn.
NO. 10 BAYLOR 70, NORTHWESTERN STATE 6
WACO, Texas (AP) - Baylor backup Seth Russell threw for 438 yards and five touchdowns while playing only the first half, and freshman KD Cannon caught three of those scores.
Cannon went streaking past the secondary for TD catches of 50, 81 and 42 yards in the first quarter. He finished with six catches for 223 yards, the second-most in school history even without playing after halftime.
The Bears (2-0) came through just fine without senor quarterback Bryce Petty, the reigning Big 12 offensive player of the year, and several injured top receivers. They won their 12th straight home game, and have scored at least 69 points six times in that streak.
Petty cracked two small bones in his back after taking a hit on his first series in the home season opener. Coach Art Briles had said Petty wouldn't play unless he was 100 percent healthy.
Northwestern State (0-2) got only a pair of field goals by Chris Moore (25 and 28 yards) and lost its 17th game in a row against FBS teams since 2005.
NO. 12 LSU 56, SAM HOUSTON STATE 0
BATON ROUGE, La. (AP) - Anthony Jennings threw three scoring passes to Travin Dural, running back Leornard Fournette scored his first touchdown, and LSU overwhelmed Sam Houston State.
All three of Dural's catches went for touchdowns, including a 94-yarder on the first offensive play LSU (2-0) ran. Fournette carried 13 times for 92 yards, highlighted by a 40-yard run. The highly hyped freshman struck a Heisman Trophy-like pose after his 4-yard touchdown reception, drawing a stern lecture from coach Les Miles.
LSU freshman quarterback Brandon Harris ran for a 46-yard score and threw his first touchdown pass to fellow freshman Malachi Dupre.
Jared Johnson completed only 8 of 25 passes for 142 yards for Sam Houston (1-2).
NO. 15 MISSISSIPPI 41, VANDERBILT 3
NASHVILLE, Tenn. (AP) - Bo Wallace threw for 320 yards and a touchdown, and Mississippi routed Vanderbilt in the Southeastern Conference opener for both teams.
The Rebels (2-0) have beaten Vanderbilt in Nashville in consecutive seasons after the Commodores (0-2) had won five of the previous six.
Ole Miss scored on seven of its first eight possessions, with the shortest drive covering 67 yards. Jaylen Walton started the scoring with a 20-yard TD run, and I'Tavius Mathers and DeVante Kincade also ran for TDs. Wallace put the Rebels up 20-0 with a 20-yard pass to Cody Core.
NO. 17 ARIZONA ST 58, NEW MEXICO 23
ALBUQUERQUE, N.M. (AP) - Taylor Kelly threw for two touchdowns and ran for another and D.J. Foster rushed for a career-high 216 yards for Arizona State.
The Sun Devils (2-0) grabbed a 22-0 first-quarter lead behind rushing touchdowns from Deantre Lewis, Kelly and Kalen Ballage.
The Lobos (0-2) pulled to 29-21 with 4:49 left in the second quarter, but Arizona State scored two touchdowns in the third quarter and New Mexico's only two points in the second half came on a blocked extra point that Brandon Branch returned 98 yards.
Kelly finished with 84 yards on the ground and one score and threw for 192 yards and two touchdowns. Ballage scored two rushing touchdowns for the Sun Devils, who compiled 423 yards rushing.
NO. 18 WISCONSIN 37, WESTERN ILLINOIS 3
MADISON, Wis. (AP) - Tanner McEvoy overcame a slow start to throw for three touchdowns and run for another, and Wisconsin pulled to beat Western Illinois.
Melvin Gordon ran for just 38 yards on 17 carries for the Badgers (1-1) with the Fighting Leathernecks (1-1) consistently stacking the box against one of the country's best rushers. McEvoy shook off a couple bad throws early to finish 23 of 28 for 283 yards with one interception.
Wisconsin led 9-3 at the half.
NO. 20 KANSAS STATE 32, IOWA STATE 28
AMES, Iowa (AP) - Jake Waters scored on an 8-yard run with 1:30 left to push Kansas State past Iowa State.
Waters threw for 239 yards and ran for a career-high 138 yards for the Wildcats (2-0, 1-0 Big 12). They trailed 28-13 late in the first half.
Jarvis West caught and threw touchdown passes and ran a punt back for a TD for Iowa State (0-2, 0-1).
NO. 21 SOUTH CAROLINA 33, EAST CAROLINA 23
COLUMBIA, S.C. (AP) - Mike Davis ran for 101 yards and two touchdowns and South Carolina bounced back from an embarrassing opening-week loss to Texas A&M.
The Gamecocks (1-1) trailed 13-7 early on with the Pirates (1-1) threatening to put another Aggies-style beating on them. But behind Davis' grinding runs and the defense's improving play, South Carolina found its footing in its first win of the season.
The victory was Steve Spurrier's 200th as a Southeastern Conference coach at Florida and South Carolina. Only Paul "Bear" Bryant with 292 and Vince Dooley with 201 have more.
NO. 21 NORTH CAROLINA 31, SAN DIEGO STATE 27
CHAPEL HILL, N.C. (AP) - Tim Scott's interception in the end zone with 14 seconds left preserved North Carolina's victory over San Diego State.
Marquise Williams threw two second-half touchdown passes and freshman Elijah Hood rushed 2 yards for the go-ahead score with 8:01 left for the Tar Heels (2-0).
They trailed by 14 points with less than 5 minutes left in the third quarter before scoring on four straight possessions to take a four-point lead, then made a late defensive stand to earn their first 2-0 start under third-year coach Larry Fedora.
Quinn Kaehler threw for a career-high 341 yards with a touchdown, then led the Aztecs (1-1) to a first-and-goal from the North Carolina 3 in the final minute. He threw a quick pass in the end zone to Lloyd Mills, but Scott jumped in front of it for the sealing interception.
NO. 23 CLEMSON 73, SOUTH CAROLINA STATE 7
CLEMSON, S.C. (AP) - Cole Stoudt completed 22 of his 31 passes for 302 yards and Clemson had its highest point total in 33 years.
The Tigers (1-1) gained 735 yards and held the outmatched FCS Bulldogs (1-1) to 44 yards.
The 73 points were the most scored by the Tigers since an 82-24 win over Wake Forest in 1981 and it was their biggest margin since beating Presbyterian 67-0 in 1957. The Tigers are 29-0 against FCS teams.
NO. 24 MISSOURI 49, TOLEDO 24
TOLEDO, Ohio (AP) - Maty Mauk threw for 325 yards and five touchdowns, and Missouri gave coach Gary Pinkel a win against his former program.
Mauk also ran for a touchdown, and the Tigers (2-0) never trailed against the Rockets (1-1) in what was expected to be a tricky road game against one of the top teams in the Mid-American Conference. Pinkel coached Toledo from 1991-2000 before taking over at Missouri. He is the winningest coach at both schools.
Toledo's Kareem Hunt ran for 148 yards and three touchdowns.
NO. 25 LOUISVILLE 66, MURRAY STATE 21
LOUISVILLE, Ky. (AP) - Louisville backup quarterback Reggie Bonnafon ran for two touchdowns and passed for another and the Cardinals (2-0) scored on nine straight possessions.
Bonnafon was 8 of 11 for 112 yards. He had touchdown runs of 8 and 16 yards and threw a 27-yard scoring pass to Michaelee Harris. Freshman L.J. Scott ran for 126 yards and a touchdown on 11 carries.
The Cardinals outgained the FCS Racers (1-1) 603-292.