Don’t double up on acetaminophen
You could be doing yourself more harm than good
Saturday, February 2, 2013
You have flu symptoms and you've been getting a little relief for the past two days by taking a cough and flu medicine every few hours. Late in the day, though, you get a headache and think about popping a couple of tablets of acetaminophen, the main ingredient in Tylenol, to treat the pain.
What you may not realize is that more than 600 medications -- both prescription and over-the-counter (OTC) -- contain acetaminophen to help relieve pain and reduce fever. Taken carefully and correctly, they can be safe and effective. But taking too much acetaminophen can lead to severe liver damage.
Acetaminophen is a common medication for relieving mild to moderate pain from headaches, muscle aches, menstrual periods, colds and sore throats, toothaches, backaches and to reduce fever. It's also used in combination medicines, which have more than one active ingredient to treat more than one symptom.
Cold and flu season hits
The National Institutes of Health (NIH) says we catch one billion colds per year and as many as 20 percent of us get the flu. Moreover, 7 in 10 people use OTC medicines to treat cold, cough and flu symptoms.
Fathia Gibril, M.D., M.HSc., a supervisory medical officer at the Food and Drug Administration (FDA), explains that consumers looking for relief from a cold or the flu may not know that acetaminophen comes in combination with many other medications used to treat those symptoms. "So if you're taking more than one medicine at a time," she says, "you may be putting yourself at risk for liver damage."
Symptoms of acetaminophen overdose may take many days to appear, and even when they become apparent, they may mimic flu or cold symptoms. The current maximum recommended adult dose of acetaminophen is 4,000 milligrams per day, To avoid exceeding that dose:
- don't take more than one OTC product containing acetaminophen,
- don't take a prescription and an OTC product containing acetaminophen, and
- don't exceed the recommended dose on any product containing acetaminophen.
"When you're at the store deciding which product to buy, check the 'Drug Facts' label of OTC cold, cough and flu products before using two or more products at the same time," Gibril says. If you’re still not sure which to buy, ask the pharmacist for advice.
FDA has a list of brand names of products containing acetaminophen here.
Listen to the experts
Acetaminophen is used in many commonly prescribed medications in combination with pain relievers such as codeine, oxycodone and hydrocodone. As of January 2011, FDA reported that overdoses from prescription medicines containing acetaminophen accounted for nearly half of all cases of acetaminophen-related liver injury in the U.S. When your healthcare professionals prescribe a drug, be sure to ask if it contains this active ingredient, and also to tell them about all other medicines (prescription and OTC) and supplements you take.
Even if you still have fever or pain, it's important not to take more than directed on the prescription or package label, notes FDA supervisory medical officer Sharon Hertz, M.D. But be careful, the word "acetaminophen" is not always spelled out in full on the container's prescription label. Abbreviations such as APAP, Acetaminoph, Acetaminop, Acetamin, or Acetam may be used instead.
When buying OTC products, Hertz suggests you make it a habit of telling the pharmacist what other medications and supplements you’re taking and asking if taking acetaminophen in addition is safe.
When the medicine is intended for children, the "Directions" section of the Drug Facts label tells you if the medicine is right for your child and how much to give. If a dose for your child's weight or age is not listed on the label and you can't tell how much to give, ask your pharmacist or doctor what to do.
If you're planning to use a medication containing acetaminophen, you should tell your healthcare professional if you have or have ever have had liver disease.
Acetaminophen and alcohol may not be a good mix, either, Hertz says. If you drink three or more alcoholic drinks a day, be sure to talk to your healthcare professional before you use a medicine containing acetaminophen.