COLUMBIA, Mo. (AP) - It was a second half to forget for James Franklin.
The Missouri sophomore quarterback threw three interceptions and lost a fumble after the break, turnovers that No. 6 Oklahoma State capitalized on in a 45-24 victory that kept the Cowboys unbeaten and ended the Tigers' 10-game home winning streak on Saturday.
"I know that I didn't play the best," Franklin said. "And it's frustrating. But being sad about it isn't going to do anything about it."
Franklin's lost fumble at the Oklahoma State 4 ruined a chance to shift momentum in the third quarter. Two of the interceptions came on tipped balls.
"That's not a bad decision, there's reasons why it happens," coach Gary Pinkel said. "I think there's a real frustration when that happens, and I think that's normal.
"It's easy to look at the quarterback and say it was this mistake and this mistake."
Franklin said rushing for 55 yards on 15 carries with a touchdown was no consolation.
"I want to be a quarterback, not an athlete," Franklin said. "Running the ball, that's good, but at the same time this offense requires a quarterback who can throw."
Joseph Randle scored four touchdowns, the last three after Missouri turnovers. Randle had 138 yards on 14 carries and had TD runs of 16, 59 and 12 yards. He also scored on a 13-yard pass in the second quarter.
Brandon Weeden had three touchdown passes after the opening snap of the second quarter. Shaun Lewis' interception and fumble recovery helped the Cowboys (7-0, 4-0 Big 12) pull away despite injuries to both starting wide receivers.
Justin Blackmon caught a touchdown pass in the first quarter but was held out as a precaution in the second half after taking a blow to the head. Hubert Anyiam was wearing a boot on his left foot in the second half.
Henry Josey had 138 yards on 25 carries, his best yardage day in the Big 12, and T.J. Moe had six catches for 103 yards and a season-best 34-yard score. All four losses for Missouri (3-4, 1-3) have come against teams ranked at the time and next up is No. 17 Texas A&M on the road.
"We have a lot of frustrated players in here, and the bottom line is that you've got to play better," Pinkel said. "You play better and you're not going to be as frustrated."
The Tigers had a strong second quarter, scoring on an 18-yard run by Kendial Lawrence and Moe's 34-yard catch from Franklin to cut the deficit to seven, before being undone by mistakes.
Lewis intercepted a pass deflected at the line at the Missouri 27 and three plays later Randle scored on a 16-yard run for a two-touchdown cushion midway through the third quarter.
Missouri appeared to regain momentum when E.J. Gaines intercepted Weeden in the end zone and returned it 54 yards, also ending Weeden's string of 194 consecutive passes without a pick. Franklin's lost fumble gave the Cowboys possession at the 12, and again they needed just three plays to respond with Randle's 59-yard jaunt making it 38-17.
Weeden was 33 for 49 for 338 yards after a sizzling start. The 28-year-old senior was 19 for 25 for 214 yards in the first quarter, with all six incompletions on drops.
Michael Harrison was wide open on a 27-yard catch and Blackmon caught an 8-yarder for his 28th receiving touchdown in 19 games. On the first play of the second quarter, Oklahoma State went up 21-3 on Weeden's 13-yard TD pass to Randle.
A trick play produced Missouri's best play of the quarter, with Franklin throwing a lateral pass to Moe and then getting it back for a 31-yard gain to the 13. But the Tigers stalled, settling for a short field goal by Grant Ressel.